Summary
A new study suggests estrogen therapy may help protect women against Alzheimer’s disease after menopause. Researchers examined health records and brain autopsy results from more than 5,000 older women who had undergone hysterectomies. Women who used estrogen-only hormone therapy around menopause had 35% lower odds of showing Alzheimer’s-related brain changes, including amyloid plaques, than those who did not use estrogen. The findings support theories that declining estrogen may influence brain health, but researchers caution that the study does not prove a cause-and-effect relationship. Previous hormone-therapy research produced mixed results. Scientists now want studies examining treatment timing, formulation, duration, and long-term Alzheimer’s outcomes.
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