Summary
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurological disorder that gradually destroys motor neurons, the nerve cells that control voluntary muscles. As these neurons deteriorate, muscles weaken and shrink, causing problems with movement, speech, swallowing, and breathing. Early signs often include weakness in the hands or limbs, particularlyon the thumb side of the hand, sometimes resulting in “split hand syndrome.” Symptoms and progression vary widely, but the disease typically worsens over time. Eventually, weakened chest and diaphragm muscles make breathing difficult, and respiratory failure becomes the most common cause of death among people with ALS.
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